安慰剂效应有多严重？或者说安慰剂效应有多普遍？ 第1页

       https://www.dana-farber.org/for-patients-and-families/becoming-a-patient/international-patients/chinese/newsroom/%E7%A0%94%E7%A9%B6%E5%8F%91%E7%8E%B0%E5%AE%89%E6%85%B0%E5%89%82%E8%83%BD%E6%94%B9%E5%96%84%E7%99%8C%E7%97%87%E5%B9%B8%E5%AD%98%E8%80%85%E5%9B%A0%E7%99%8C%E7%97%87%E5%BC%95%E8%B5%B7%E7%9A%84%E7%96%B2%E7%B4%AF%E6%84%9F%E2%80%94%E2%80%94%E5%8D%B3%E4%BD%BF%E6%82%A3%E8%80%85%E7%9F%A5%E6%99%93%E5%85%B6%E6%89%80%E7%94%A8%E8%8D%AF%E7%89%A9%E6%97%A0%E4%BB%BB%E4%BD%95%E7%96%97%E6%95%88placebo/ https://nejmqianyan.cn/article/YXQYra1907805?sg=AbW1NGsHw3NxPd6F  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784544/#:~:text='To%20cure%20sometimes%2C%20to%20relieve,I'd%20said%20that'.     

       Quotes from Hippocrates:  “Make a habit of two things: to help; or at least to do no harm.”  “Cure sometimes, treat often, comfort always.”  “Wherever the art of medicine is loved, there is also a love of humanity.”  “Many admire, few know.”  “Science is the father of knowledge, but opinion breeds ignorance.”  “There are in fact two things, science and opinion; the former begets knowledge, the latter ignorance.”  “To do nothing is also a good remedy.”     

       参考文献 Colloca L, Finniss D. Nocebo effects, patient-clinician communication, and therapeutic outcomes. JAMA 2012;307:567-568. O’Connor AM, Pennie RA, Dales RE. Framing effects on expectations, decisions, and side effects experienced: the case of influenza immunization. J Clin Epidemiol 1996;49:1271-1276. Wells RE, Kaptchuk TJ. To tell the truth, the whole truth, may do patients harm: the problem of the nocebo effect for informed consent. Am J Bioeth 2012;12:22-29. Daniali H, Flaten MA. A qualitative systematic review of effects of provider characteristics and nonverbal behavior on pain, and placebo and nocebo effects. Front Psychiatry 2019;10:242-242. Hróbjartsson A, Gøtzsche PC. Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med 2001;344:1594-1602. Fava M, Evins AE, Dorer DJ, Schoenfeld DA. The problem of the placebo response in clinical trials for psychiatric disorders: culprits, possible remedies, and a novel study design approach. Psychother Psychosom 2003;72:115-127. Enck P, Grundy D, Klosterhalfen S. A novel placebo-controlled clinical study design without ethical concerns — the free choice paradigm. Med Hypotheses 2012;79:880-882. Colloca L, Benedetti F. How prior experience shapes placebo analgesia. Pain 2006;124:126-133. Rief W, Barsky AJ, Glombiewski JA, Nestoriuc Y, Glaesmer H, Braehler E. Assessing general side effects in clinical trials: reference data from the general population. Pharmacoepidemiol Drug Saf 2011;20:405-415. Colloca L, Schenk LA, Nathan DE, Robinson OJ, Grillon C. When expectancies are violated: a functional magnetic resonance imaging study. Clin Pharmacol Ther 2019;106:1246-1252. Colloca L. The placebo effect in pain therapies. Annu Rev Pharmacol Toxicol 2019;59:191-211. Barsky AJ, Saintfort R, Rogers MP, Borus JF. Nonspecific medication side effects and the nocebo phenomenon. JAMA 2002;287:622-627. Vase L, Amanzio M, Price DD. Nocebo vs. placebo: the challenges of trial design in analgesia research. Clin Pharmacol Ther 2015;97:143-150. Vase L, Vollert J, Finnerup NB, et al. Predictors of the placebo analgesia response in randomized controlled trials of chronic pain: a meta-analysis of the individual data from nine industrially sponsored trials. Pain 2015;156:1795-1802. Colloca L. Placebo, nocebo, and learning mechanisms. Handb Exp Pharmacol 2014;225:17-35. Colloca L, Miller FG. Role of expectations in health. Curr Opin Psychiatry 2011;24:149-155. Vase L, Petersen GL, Riley JL III, Price DD. Factors contributing to large analgesic effects in placebo mechanism studies conducted between 2002 and 2007. Pain 2009;145:36-44. Dolgin E. Fluctuating baseline pain implicated in failure of clinical trials. Nat Med 2010;16:1053-1053. Weimer K, Colloca L, Enck P. Placebo effects in psychiatry: mediators and moderators. Lancet Psychiatry 2015;2:246-257. Rosenzweig P, Brohier S, Zipfel A. The placebo effect in healthy volunteers: influence of experimental conditions on the adverse events profile during phase I studies. Clin Pharmacol Ther 1993;54:578-583. Häuser W, Sarzi-Puttini P, Tölle TR, Wolfe F. Placebo and nocebo responses in randomised controlled trials of drugs applying for approval for fibromyalgia syndrome treatment: systematic review and meta-analysis. Clin Exp Rheumatol 2012;30:Suppl 74:78-87. Rief W, Avorn J, Barsky AJ. Medication-attributed adverse effects in placebo groups: implications for assessment of adverse effects. Arch Intern Med 2006;166:155-160. Amanzio M, Benedetti F. Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems. J Neurosci 1999;19:484-494. Eippert F, Bingel U, Schoell ED, et al. Activation of the opioidergic descending pain control system underlies placebo analgesia. Neuron 2009;63:533-543. Benedetti F, Amanzio M, Rosato R, Blanchard C. Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors. Nat Med 2011;17:1228-1230. Benedetti F, Colloca L, Torre E, et al. Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus. Nat Neurosci 2004;7:587-588. Lidstone SC, Schulzer M, Dinelle K, et al. Effects of expectation on placebo-induced dopamine release in Parkinson disease. Arch Gen Psychiatry 2010;67:857-865. Kessner S, Sprenger C, Wrobel N, Wiech K, Bingel U. Effect of oxytocin on placebo analgesia: a randomized study. JAMA 2013;310:1733-1735. Colloca L, Pine DS, Ernst M, Miller FG, Grillon C. Vasopressin boosts placebo analgesic effects in women: a randomized trial. Biol Psychiatry 2016;79:794-802. Skyt I, Moslemi K, Baastrup C, et al. Dopaminergic tone does not influence pain levels during placebo interventions in patients with chronic neuropathic pain. Pain 2018;159:261-272. Zunhammer M, Gerardi M, Bingel U. The effect of dopamine on conditioned placebo analgesia in healthy individuals: a double-blind randomized trial. Psychopharmacology (Berl) 2018;235:2587-2595. Benedetti F, Amanzio M, Vighetti S, Asteggiano G. The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect. J Neurosci 2006;26:12014-12022. Benedetti F, Amanzio M, Casadio C, Oliaro A, Maggi G. Blockade of nocebo hyperalgesia by the cholecystokinin antagonist proglumide. Pain 1997;71:135-140. Colloca L, Wang Y, Martinez PE, et al. OPRM1 rs1799971, COMT rs4680, and FAAH rs324420 genes interact with placebo procedures to induce hypoalgesia. Pain 2019;160:1824-1834. Hall KT, Loscalzo J, Kaptchuk TJ. Genetics and the placebo effect: the placebome. Trends Mol Med 2015;21:285-294. Wendt L, Albring A, Benson S, et al. Catechol-O-methyltransferase Val158Met polymorphism is associated with somatosensory amplification and nocebo responses. PLoS One 2014;9(9):e107665-e107665. Zunhammer M, Bingel U, Wager TD. Placebo effects on the neurologic pain signature: a meta-analysis of individual participant functional magnetic resonance imaging data. JAMA Neurol 2018;75:1321-1330. Wager TD, Atlas LY, Lindquist MA, Roy M, Woo C-W, Kross E. An fMRI-based neurologic signature of physical pain. N Engl J Med 2013;368:1388-1397. Tinnermann A, Geuter S, Sprenger C, Finsterbusch J, Büchel C. Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia. Science 2017;358:105-108. Geuter S, Büchel C. Facilitation of pain in the human spinal cord by nocebo treatment. J Neurosci 2013;33:13784-13790. Bingel U, Wanigasekera V, Wiech K, et al. The effect of treatment expectation on drug efficacy: imaging the analgesic benefit of the opioid remifentanil. Sci Transl Med 2011;3:70ra14-70ra14. Colagiuri B, Schenk LA, Kessler MD, Dorsey SG, Colloca L. The placebo effect: from concepts to genes. Neuroscience 2015;307:171-190. Colloca L, Miller FG. Harnessing the placebo effect: the need for translational research. Philos Trans R Soc Lond B Biol Sci 2011;366:1922-1930. Colloca L, Miller FG. How placebo responses are formed: a learning perspective. Philos Trans R Soc Lond B Biol Sci 2011;366:1859-1869. Dekker E, Groen J. Reproducible psychogenic attacks of asthma; a laboratory study. J Psychosom Res 1956;1:58-67. Rheker J, Winkler A, Doering BK, Rief W. Learning to experience side effects after antidepressant intake — results from a randomized, controlled, double-blind study. Psychopharmacology (Berl) 2017;234:329-338. Colloca L, Sigaudo M, Benedetti F. The role of learning in nocebo and placebo effects. Pain 2008;136:211-218. Jensen KB, Kaptchuk TJ, Kirsch I, et al. Nonconscious activation of placebo and nocebo pain responses. Proc Natl Acad Sci U S A 2012;109:15959-15964. Colloca L, Benedetti F. Placebo analgesia induced by social observational learning. Pain 2009;144:28-34. Hunter T, Siess F, Colloca L. Socially induced placebo analgesia: a comparison of a pre-recorded versus live face-to-face observation. Eur J Pain 2014;18:914-922. Egorova N, Park J, Orr SP, Kirsch I, Gollub RL, Kong J. Not seeing or feeling is still believing: conscious and non-conscious pain modulation after direct and observational learning. Sci Rep 2015;5:16809-16809. Vögtle E, Barke A, Kröner-Herwig B. Nocebo hyperalgesia induced by social observational learning. Pain 2013;154:1427-1433. Swider K, Bąbel P. The effect of the sex of a model on nocebo hyperalgesia induced by social observational learning. Pain 2013;154:1312-1317. Świder K, Bąbel P. The effect of the type and colour of placebo stimuli on placebo effects induced by observational learning. PLoS One 2016;11(6):e0158363-e0158363. Lorber W, Mazzoni G, Kirsch I. Illness by suggestion: expectancy, modeling, and gender in the production of psychosomatic symptoms. Ann Behav Med 2007;33:112-116. Lees-Haley PR, Brown RS. Biases in perception and reporting following a perceived toxic exposure. Percept Mot Skills 1992;75:531-544. Gupta A, Thompson D, Whitehouse A, et al. Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phase. Lancet 2017;389:2473-2481. Matthews A, Herrett E, Gasparrini A, et al. Impact of statin related media coverage on use of statins: interrupted time series analysis with UK primary care data. BMJ 2016;353:i3283-i3283. Faasse K, Cundy T, Petrie KJ. Medicine and the media. Thyroxine: anatomy of a health scare. BMJ 2009;339:b5613-b5613. Baker DB, Greenland S, Mendlein J, Harmon P. A health study of two communities near the Stringfellow Waste Disposal site. Arch Environ Health 1988;43:325-334. Locher C, Frey Nascimento A, Kossowsky J, Meyer A, Gaab J. Open-label placebo response — does optimism matter? A secondary-analysis of a randomized controlled trial. J Psychosom Res 2019;116:25-30. Uhlenhuth EH, Alexander PE, Dempsey GM, Jones W, Coleman BS, Swiontek AM. Medication side effects in anxious patients: negative placebo responses? J Affect Disord 1998;47:183-190. Barsky AJ, Orav EJ, Ahern DK, Rogers MP, Gruen SD, Liang MH. Somatic style and symptom reporting in rheumatoid arthritis. Psychosomatics 1999;40:396-403. Davis C, Ralevski E, Kennedy SH, Neitzert C. The role of personality factors in the reporting of side effect complaints to moclobemide and placebo: a study of healthy male and female volunteers. J Clin Psychopharmacol 1995;15:347-352. Blasini M, Peiris N, Wright T, Colloca L. The role of patient-practitioner relationships in placebo and nocebo phenomena. Int Rev Neurobiol 2018;139:211-231. Rakel D, Barrett B, Zhang Z, et al. Perception of empathy in the therapeutic encounter: effects on the common cold. Patient Educ Couns 2011;85:390-397. Gracely RH, Dubner R, Deeter WR, Wolskee PJ. Clinicians’ expectations influence placebo analgesia. Lancet 1985;1:43-43. Petersen GL, Finnerup NB, Grosen K, et al. Expectations and positive emotional feelings accompany reductions in ongoing and evoked neuropathic pain following placebo interventions. Pain 2014;155:2687-2698. Kirchhof J, Petrakova L, Brinkhoff A, et al. Learned immunosuppressive placebo responses in renal transplant patients. Proc Natl Acad Sci U S A 2018;115:4223-4227. Colloca L, Lopiano L, Lanotte M, Benedetti F. Overt versus covert treatment for pain, anxiety, and Parkinson’s disease. Lancet Neurol 2004;3:679-684. Silvestri A, Galetta P, Cerquetani E, et al. Report of erectile dysfunction after therapy with beta-blockers is related to patient knowledge of side effects and is reversed by placebo. Eur Heart J 2003;24:1928-1932. Mondaini N, Gontero P, Giubilei G, et al. Finasteride 5 mg and sexual side effects: how many of these are related to a nocebo phenomenon? J Sex Med 2007;4:1708-1712. Luparello T, Lyons HA, Bleecker ER, McFadden ER Jr. Influences of suggestion on airway reactivity in asthmatic subjects. Psychosom Med 1968;30:819-825. Luparello TJ, Leist N, Lourie CH, Sweet P. The interaction of psychologic stimuli and pharmacologic agents on airway reactivity in asthmatic subjects. Psychosom Med 1970;32:509-513. Klosterhalfen S, Kellermann S, Stockhorst U, et al. Latent inhibition of rotation chair-induced nausea in healthy male and female volunteers. Psychosom Med 2005;67:335-340. Kam-Hansen S, Jakubowski M, Kelley JM, et al. Altered placebo and drug labeling changes the outcome of episodic migraine attacks. Sci Transl Med 2014;6:218ra5-218ra5. Krank MD, Hinson RE, Siegel S. Conditional hyperalgesia is elicited by environmental signals of morphine. Behav Neural Biol 1981;32:148-157. Valone JM, Randall CK, Kraemer PJ, Bardo MT. Olfactory cues and morphine-induced conditioned analgesia in rats. Pharmacol Biochem Behav 1998;60:115-118. Bardo MT, Valone JM. Morphine-conditioned analgesia using a taste cue: dissociation of taste aversion and analgesia. Psychopharmacology (Berl) 1994;114:269-274. Colloca L, Enck P, DeGrazia D. Relieving pain using dose-extending placebos: a scoping review. Pain 2016;157:1590-1598. Ader R, Mercurio MG, Walton J, et al. Conditioned pharmacotherapeutic effects: a preliminary study. Psychosom Med 2010;72:192-197. Perlis M, Grandner M, Zee J, et al. Durability of treatment response to zolpidem with three different maintenance regimens: a preliminary study. Sleep Med 2015;16:1160-1168. Sandler AD, Bodfish JW. Open-label use of placebos in the treatment of ADHD: a pilot study. Child Care Health Dev 2008;34:104-110. Kamen C, Tejani MA, Chandwani K, et al. Anticipatory nausea and vomiting due to chemotherapy. Eur J Pharmacol 2014;722:172-179. Taddio A, Shah V, Gilbert-MacLeod C, Katz J. Conditioning and hyperalgesia in newborns exposed to repeated heel lances. JAMA 2002;288:857-861. Linde K, Witt CM, Streng A, et al. The impact of patient expectations on outcomes in four randomized controlled trials of acupuncture in patients with chronic pain. Pain 2007;128:264-271. Wartolowska K, Judge A, Hopewell S, et al. Use of placebo controls in the evaluation of surgery: systematic review. BMJ 2014;348:g3253-g3253. Vase L, Robinson ME, Verne GN, Price DD. The contributions of suggestion, desire, and expectation to placebo effects in irritable bowel syndrome patients: an empirical investigation. Pain 2003;105:17-25. Rief W, Shedden-Mora MC, Laferton JA, et al. Preoperative optimization of patient expectations improves long-term outcome in heart surgery patients: results of the randomized controlled PSY-HEART trial. BMC Med 2017;15:4-4. Egbert LD, Battit GE, Welch CE, Bartlett MK. Reduction of postoperative pain by encouragement and instruction of patients — a study of doctor-patient rapport. N Engl J Med 1964;270:825-827. Pattullo GG, Colloca L. The opioid epidemic: could enhancing placebo effects be part of the solution? Br J Anaesth 2019;122(6):e209-e210. Kaptchuk TJ, Miller FG. Open label placebo: can honestly prescribed placebos evoke meaningful therapeutic benefits? BMJ 2018;363:k3889-k3889. Colloca L. Nocebo effects can make you feel pain. Science 2017;358:44-44. Colloca L, Miller FG. The nocebo effect and its relevance for clinical practice. Psychosom Med 2011;73:598-603.