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目前人类对免疫系统的认识到了什么阶段? 第1页

  

user avatar   mai-wen-xue-67 网友的相关建议: 
      

其实很早,早在上世纪六十年代, 人类对自身免疫疾病就已经有了比较深刻的认识。

例如, 天疱疮、肾小球肾炎等。

自身免疫疾病的用药套路, 21 世纪的头二十年和半个世纪前相比, 并没有太大的变化。

如果俺没记错的话, 白塞氏病在上世纪 80 年代就已经写进了祖国的《眼科学》、《皮肤病学》、《妇产科学》以及 《口腔内科学》以及 《口腔组织病理学》的课本, 因为众所周知的口-眼-生殖器三联征。


       https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566249/pdf/envhper00522-0014.pdf     


分子水平的认知并不是线性的。 您需要领会到自身免疫疾病的起病是一个或者多个复合和/或“复杂系统”相互作用的结果。

也因此, 才会诉诸“假说”。



越来越多的证据表明,环境可能导致自身免疫和自身免疫性疾病。

当免疫系统错误地攻击体内正常、健康的组织和器官时,自身免疫性疾病就会发生。

I 型糖尿病、类风湿性关节炎、克陇病、乳糜泻和银屑病只是自身免疫性疾病常见的几个实例。


       https://www.nih.gov/research-training/accelerating-medicines-partnership-amp/autoimmune-immune-mediated-diseases     


2021年12月启动的AMP自身免疫和免疫介导的疾病(AMP AIM)计划旨在加深对导致炎症和自身免疫疾病的细胞和分子相互作用的理解。AMP AIM研究人员将专注于类风湿性关节炎、系统性红斑狼疮、银屑病、关节炎和干燥综合征。

通过这些研究获得的知识将推动开发新的和强化的自身免疫性疾病的疗法。此外,AMP AIM将推动新的研究工具、数据存储平台和数据共享技术的发展。

自身免疫性疾病影响着超过2350万美国人。

最近的研究表明,这些疾病正变得越来越普遍。

在这些情况下,身体的免疫反应是如此过度和持久,以至于它们可以严重损害许多组织和器官系统,这可能对健康、福祉和生活质量产生破坏性影响。科学家很难开发新的治疗方法,医生也很难护理慢性自身免疫性疾病患者,因为这些疾病非常复杂。此外,每个人都有独特的基因构成,并在其生命过程中发展自己的免疫系统。由于这些因素,没有一种治疗方法对每个人或每种自身免疫性疾病都有效。

另一方面,许多自身免疫性疾病有相似之处

它们有共同的炎症途径、临床特征和对治疗的反应。

通过识别和描述许多自身免疫性疾病共有的分子和细胞水平的途径和相互作用,以及特定疾病特有的途径和相互作用,AMP AIM的科学家可以为开发新的疗法和诊断工具开辟道路。


       https://www.niaid.nih.gov/diseases-conditions/autoimmune-diseases     






“目前人类对免疫系统的认识到了什么阶段?

免疫系统作为人体重要的组成部分,目前涉及免疫系统的疾病,如红斑狼疮,类风湿性关节炎,白塞病,干燥症等,在发病原因治疗措施方面基本无法精准诊治,为何对免疫系统的认识如此缺失,何时会有突破性的认识?”


答:

如果您选择悲观, 那么您可能会十分悲观,因为人类连感冒(广义的感冒明年就可以包括 OMICRON 了)都治不好, 其实是拖好的。

肾衰竭的终极解决办法还是换肾, 肝硬化的终极解决办法还是换肝。

......


悲观的终极解决办法倒不是换脑,

而是到知乎首页搜索“笑话”。


【未完待续】


       Jacobson DL, Gange SJ, Rose NR, Graham NM. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol. 1997 Sep;84(3):223–243. [PubMed] [Google Scholar] Ross R. Mechanisms of atherosclerosis--a review. Adv Nephrol Necker Hosp. 1990;19:79–86. [PubMed] [Google Scholar] Galperin C, Gershwin ME. Immunopathogenesis of gastrointestinal and hepatobiliary diseases. JAMA. 1997 Dec 10;278(22):1946–1955. [PubMed] [Google Scholar] Beeson PB. Age and sex associations of 40 autoimmune diseases. Am J Med. 1994 May;96(5):457–462. [PubMed] [Google Scholar] Cutolo M, Sulli A, Seriolo B, Accardo S, Masi AT. Estrogens, the immune response and autoimmunity. Clin Exp Rheumatol. 1995 Mar-Apr;13(2):217–226. [PubMed] [Google Scholar] Sakić B, Szechtman H, Denburg JA, Gorny G, Kolb B, Whishaw IQ. Progressive atrophy of pyramidal neuron dendrites in autoimmune MRL-lpr mice. J Neuroimmunol. 1998 Jul 1;87(1-2):162–170. [PubMed] [Google Scholar] Roubinian JR, Talal N, Greenspan JS, Goodman JR, Siiteri PK. Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice. J Exp Med. 1978 Jun 1;147(6):1568–1583. [PMC free article] [PubMed] [Google Scholar] Hooks JJ, Jordan GW, Cupps T, Moutsopoulos HM, Fauci AS, Notkins AL. Multiple interferons in the circulation of patients with systemic lupus erythematosus and vasculitis. Arthritis Rheum. 1982 Apr;25(4):396–400. [PubMed] [Google Scholar] Trembleau S, Germann T, Gately MK, Adorini L. The role of IL-12 in the induction of organ-specific autoimmune diseases. Immunol Today. 1995 Aug;16(8):383–386. [PubMed] [Google Scholar] McKall-Faienza KJ, Kawai K, Kündig TM, Odermatt B, Bachmann MF, Zakarian A, Mak TW, Ohashi PS. Absence of TNFRp55 influences virus-induced autoimmunity despite efficient lymphocytic infiltration. Int Immunol. 1998 Apr;10(4):405–412. [PubMed] [Google Scholar] Schattner A. Lymphokines in autoimmunity--a critical review. Clin Immunol Immunopathol. 1994 Mar;70(3):177–189. [PubMed] [Google Scholar] Webster EL, Torpy DJ, Elenkov IJ, Chrousos GP. Corticotropin-releasing hormone and inflammation. Ann N Y Acad Sci. 1998 May 1;840:21–32. [PubMed] [Google Scholar] Yoshida S, Gershwin ME. Autoimmunity and selected environmental factors of disease induction. Semin Arthritis Rheum. 1993 Jun;22(6):399–419. [PubMed] [Google Scholar] Singer PA, Theofilopoulos AN. T-cell receptor V beta repertoire expression in murine models of SLE. Immunol Rev. 1990 Dec;118:103–127. [PubMed] [Google Scholar] Druet P. Contribution of immunological reactions to nephrotoxicity. Toxicol Lett. 1989 Mar;46(1-3):55–64. [PubMed] [Google Scholar] Pettinelli CB, McFarlin DE. Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+ 2- T lymphocytes. J Immunol. 1981 Oct;127(4):1420–1423. [PubMed] [Google Scholar] Waldor MK, Sriram S, Hardy R, Herzenberg LA, Herzenberg LA, Lanier L, Lim M, Steinman L. Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker. Science. 1985 Jan 25;227(4685):415–417. [PubMed] [Google Scholar] Kong YM, Waldmann H, Cobbold S, Giraldo AA, Fuller BE, Simon LL. Pathogenic mechanisms in murine autoimmune thyroiditis: short- and long-term effects of in vivo depletion of CD4+ and CD8+ cells. Clin Exp Immunol. 1989 Sep;77(3):428–433. [PMC free article] [PubMed] [Google Scholar] Bretscher P, Cohn M. A theory of self-nonself discrimination. Science. 1970 Sep 11;169(3950):1042–1049. [PubMed] [Google Scholar] Hodgkin PD, Basten A. B cell activation, tolerance and antigen-presenting function. Curr Opin Immunol. 1995 Feb;7(1):121–129. [PubMed] [Google Scholar] Purrmann J, Arendt G, Cleveland S, Borchard F, Fürst W, Gemsa R, Bertrams J, Hengels KJ. Association of Crohn's disease and multiple sclerosis. Is there a common background? J Clin Gastroenterol. 1992 Jan;14(1):43–46. [PubMed] [Google Scholar] Lorber M, Gershwin ME, Shoenfeld Y. The coexistence of systemic lupus erythematosus with other autoimmune diseases: the kaleidoscope of autoimmunity. Semin Arthritis Rheum. 1994 Oct;24(2):105–113. [PubMed] [Google Scholar] Ginn LR, Lin JP, Plotz PH, Bale SJ, Wilder RL, Mbauya A, Miller FW. Familial autoimmunity in pedigrees of idiopathic inflammatory myopathy patients suggests common genetic risk factors for many autoimmune diseases. Arthritis Rheum. 1998 Mar;41(3):400–405. [PubMed] [Google Scholar] Golovanova NK, Gracheva EV, Basharova LA, Kozlov SG, Lyakishev AA, Prokazova NV, Bergelson LD. Autoantibodies to gangliosides in sera of atherosclerotic patients. Clin Chim Acta. 1998 Apr 27;272(2):197–207. [PubMed] [Google Scholar] Holvoet P, Collen D. Oxidation of low density lipoproteins in the pathogenesis of atherosclerosis. Atherosclerosis. 1998 Apr;137 (Suppl):S33–S38. [PubMed] [Google Scholar] Xu Q, Willeit J, Marosi M, Kleindienst R, Oberhollenzer F, Kiechl S, Stulnig T, Luef G, Wick G. Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis. Lancet. 1993 Jan 30;341(8840):255–259. [PubMed] [Google Scholar] Xu Q, Dietrich H, Steiner HJ, Gown AM, Schoel B, Mikuz G, Kaufmann SH, Wick G. Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65. Arterioscler Thromb. 1992 Jul;12(7):789–799. [PubMed] [Google Scholar] Libby P, Warner SJ, Salomon RN, Birinyi LK. Production of platelet-derived growth factor-like mitogen by smooth-muscle cells from human atheroma. N Engl J Med. 1988 Jun 9;318(23):1493–1498. [PubMed] [Google Scholar] Xu QB, Oberhuber G, Gruschwitz M, Wick G. Immunology of atherosclerosis: cellular composition and major histocompatibility complex class II antigen expression in aortic intima, fatty streaks, and atherosclerotic plaques in young and aged human specimens. Clin Immunol Immunopathol. 1990 Sep;56(3):344–359. [PubMed] [Google Scholar] Shinitzky M, Deckmann M, Kessler A, Sirota P, Rabbs A, Elizur A. Platelet autoantibodies in dementia and schizophrenia. Possible implication for mental disorders. Ann N Y Acad Sci. 1991;621:205–217. [PubMed] [Google Scholar] Barak V, Barak Y, Levine J, Nisman B, Roisman I. Changes in interleukin-1 beta and soluble interleukin-2 receptor levels in CSF and serum of schizophrenic patients. J Basic Clin Physiol Pharmacol. 1995;6(1):61–69. [PubMed] [Google Scholar] Fichorova RN, Boulanov ID. Anti-seminal plasma antibodies associated with infertility: I. Serum antibodies against normozoospermic seminal plasma in patients with unexplained infertility. Am J Reprod Immunol. 1996 Oct;36(4):198–203. [PubMed] [Google Scholar] Geva E, Amit A, Lerner-Geva L, Lessing JB. Autoimmunity and reproduction. Fertil Steril. 1997 Apr;67(4):599–611. [PubMed] [Google Scholar] Kraus-Mackiw E. Sympathetic ophthalmia, a genuine autoimmune disease. Curr Eye Res. 1990;9 (Suppl):1–5. [PubMed] [Google Scholar] Flickinger CJ, Baran ML, Howards SS, Herr JC. Epididymal obstruction during development results in antisperm autoantibodies at puberty in rats. J Androl. 1998 Mar-Apr;19(2):136–144. [PubMed] [Google Scholar] Jarow JP, Goluboff ET, Chang TS, Marshall FF. Relationship between antisperm antibodies and testicular histologic changes in humans after vasectomy. Urology. 1994 Apr;43(4):521–524. [PubMed] [Google Scholar] von Herrath MG, Dyrberg T, Oldstone MB. Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice. J Clin Invest. 1996 Sep 15;98(6):1324–1331. [PMC free article] [PubMed] [Google Scholar] Griem P, Panthel K, Kalbacher H, Gleichmann E. Alteration of a model antigen by Au(III) leads to T cell sensitization to cryptic peptides. Eur J Immunol. 1996 Feb;26(2):279–287. [PubMed] [Google Scholar] Kubicka-Muranyi M, Kremer J, Rottmann N, Lübben B, Albers R, Bloksma N, Lührmann R, Gleichmann E. Murine systemic autoimmune disease induced by mercuric chloride: T helper cells reacting to self proteins. Int Arch Allergy Immunol. 1996 Jan;109(1):11–20. [PubMed] [Google Scholar] Christie DJ. Specificity of drug-induced immune cytopenias. Transfus Med Rev. 1993 Oct;7(4):230–241. [PubMed] [Google Scholar] Christen U, Quinn J, Yeaman SJ, Kenna JG, Clarke JB, Gandolfi AJ, Gut J. Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis. Molecular mimicry of trifluoroacetyl-lysine by lipoic acid. Eur J Biochem. 1994 Aug 1;223(3):1035–1047. [PubMed] [Google Scholar] Furst SM, Luedke D, Gaw HH, Reich R, Gandolfi AJ. Demonstration of a cellular immune response in halothane-exposed guinea pigs. Toxicol Appl Pharmacol. 1997 Apr;143(2):245–255. [PubMed] [Google Scholar] Dell A, Antone SM, Gauntt CJ, Crossley CA, Clark WA, Cunningham MW. Autoimmune determinants of rheumatic carditis: localization of epitopes in human cardiac myosin. Eur Heart J. 1991 Aug;12 (Suppl 500):158–162. [PubMed] [Google Scholar] Guilherme L, Cunha-Neto E, Coelho V, Snitcowsky R, Pomerantzeff PM, Assis RV, Pedra F, Neumann J, Goldberg A, Patarroyo ME, et al. Human heart-infiltrating T-cell clones from rheumatic heart disease patients recognize both streptococcal and cardiac proteins. Circulation. 1995 Aug 1;92(3):415–420. [PubMed] [Google Scholar] Bech K. Yersinia enterocolitica and thyroid autoimmunity. Autoimmunity. 1990;7(4):291–294. [PubMed] [Google Scholar] Wolf MW, Misaki T, Bech K, Tvede M, Silva JE, Ingbar SH. Immunoglobulins of patients recovering from Yersinia enterocolitica infections exhibit Graves' disease-like activity in human thyroid membranes. Thyroid. 1991 Winter;1(4):315–320. [PubMed] [Google Scholar] Wenzel BE, Heesemann J, Wenzel KW, Scriba PC. Antibodies to plasmid-encoded proteins of enteropathogenic Yersinia in patients with autoimmune thyroid disease. Lancet. 1988 Jan 2;1(8575-6):56–56. [PubMed] [Google Scholar] Luo G, Seetharamaiah GS, Niesel DW, Zhang H, Peterson JW, Prabhakar BS, Klimpel GR. Purification and characterization of Yersinia enterocolitica envelope proteins which induce antibodies that react with human thyrotropin receptor. J Immunol. 1994 Mar 1;152(5):2555–2561. [PubMed] [Google Scholar] Friedman SM, Posnett DN, Tumang JR, Cole BC, Crow MK. A potential role for microbial superantigens in the pathogenesis of systemic autoimmune disease. Arthritis Rheum. 1991 Apr;34(4):468–480. [PubMed] [Google Scholar] al-Daccak R, Mehindate K, Hébert J, Rink L, Mecheri S, Mourad W. Mycoplasma arthritidis-derived superantigen induces proinflammatory monokine gene expression in the THP-1 human monocytic cell line. Infect Immun. 1994 Jun;62(6):2409–2416. [PMC free article] [PubMed] [Google Scholar] Bhardwaj N, Hodtsev AS, Nisanian A, Kabak S, Friedman SM, Cole BC, Posnett DN. Human T-cell responses to Mycoplasma arthritidis-derived superantigen. Infect Immun. 1994 Jan;62(1):135–144. [PMC free article] [PubMed] [Google Scholar] Tumang JR, Cherniack EP, Gietl DM, Cole BC, Russo C, Crow MK, Friedman SM. T helper cell-dependent, microbial superantigen-induced murine B cell activation: polyclonal and antigen-specific antibody responses. J Immunol. 1991 Jul 15;147(2):432–438. [PubMed] [Google Scholar] Heward J, Gough SC. Genetic susceptibility to the development of autoimmune disease. Clin Sci (Lond) 1997 Dec;93(6):479–491. [PubMed] [Google Scholar] Altmann DM, Sansom D, Marsh SG. What is the basis for HLA-DQ associations with autoimmune disease? Immunol Today. 1991 Aug;12(8):267–270. [PubMed] [Google Scholar] Theofilopoulos AN. The basis of autoimmunity: Part II. Genetic predisposition. Immunol Today. 1995 Mar;16(3):150–159. [PubMed] [Google Scholar] Steinman L, Oksenberg JR, Bernard CC. Association of susceptibility to multiple sclerosis with TCR genes. Immunol Today. 1992 Feb;13(2):49–51. [PubMed] [Google Scholar] Imberti L, Sottini A, Primi D. T cell repertoire and autoimmune diseases. Immunol Res. 1993;12(2):149–167. [PubMed] [Google Scholar] Seboun E, Robinson MA, Doolittle TH, Ciulla TA, Kindt TJ, Hauser SL. A susceptibility locus for multiple sclerosis is linked to the T cell receptor beta chain complex. Cell. 1989 Jun 30;57(7):1095–1100. [PubMed] [Google Scholar] Hillert J, Leng C, Olerup O. T-cell receptor alpha chain germline gene polymorphisms in multiple sclerosis. Neurology. 1992 Jan;42(1):80–84. [PubMed] [Google Scholar] Constantinescu CS, Hilliard B, Fujioka T, Bhopale MK, Calida D, Rostami AM. Pathogenesis of neuroimmunologic diseases. Experimental models. Immunol Res. 1998;17(1-2):217–227. [PubMed] [Google Scholar] Lo D. Animal models of human disease. Transgenic and knockout models of autoimmunity: Building a better disease? Clin Immunol Immunopathol. 1996 May;79(2):96–104. [PubMed] [Google Scholar] Theofilopoulos AN. The basis of autoimmunity: Part I. Mechanisms of aberrant self-recognition. Immunol Today. 1995 Feb;16(2):90–98. [PubMed] [Google Scholar] Bigazzi PE. Autoimmunity caused by xenobiotics. Toxicology. 1997 Apr 11;119(1):1–21. [PubMed] [Google Scholar]      





  

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